Trainer Aidan O'Brien claimed a record-equalling seventh Derby success as Anthony Van Dyck beat Madhmoon by half a length at Epsom.
Frankie Dettori steered Anapurna to a narrow victory in the Investec Oaks at Epsom on Friday.
Defoe sprang a surprise for trainer Roger Varian by winning Friday's Investec Coronation Cup at Epsom.
Connections of Frankellina will wait until the weekend before deciding if she will participate in the Investec Oaks on May 31.
Aidan O'Brien says Hermosa will target either the Investec Oaks at Epsom or the Tattersalls Irish 1,000 Guineas later this month.
Trainer Charlie Appleby feels Line Of Duty has the right experience to be a serious threat at next month's Epsom Derby.
Magna Grecia and Hermosa are being lined up for the Irish Guineas later this month after their weekend successes at Newmarket.